A team of Japanese researchers at Nagoya University has made a discovery that could change the way we understand aging. They found that aldehydes, which
We know that a host of factors play into Alzheimer's risk, including the makeup of our gut bacteria.
In a global research effort, scientists have uncovered a relationship between metabolism problems in the brain and a range of neuropsychiatric and neurodegenerative disorders, from autism to Alzheimer's disease and more.
Autism spectrum disorder (ASD) encompasses neurodevelopmental conditions where patients display repetitive behavior and impaired sociality. Genetic
The findings may also have implications for learning and memory disorders, including Fragile X syndrome.
Investigators have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, neuron specialization and other brain functions.
New research conducted by the Medical Research Council (MRC) has identified genetic variants in two genes that have some of the largest impacts on obesity risk discovered to date. The discovery of rare variants in the genes BSN and APBA1 are some of the first obesity-related genes identified for
A new study suggests that certain kinds of Alzheimer's disease may be able to transfer from donors to recipients during bone marrow transplants.
Researchers have released Kilosort4, the newest version of a popular spike-sorting software that enables scientists to make sense of the mountains of data collected from recording the simultaneous activity of hundreds of neurons.
Why do some memories last, while others fade away? Surprisingly, the answer may be broken DNA and inflammation in the brain.
Mitochondria, organelles with an inner and outer membrane, are responsible for creating the energy that cells use to survive, and their morphology is key to accomplishing this task. The inner mitochondrial membrane contains folds, called cristae, that maximize the surface area available for mitochondrial energetic processes.
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This burgeoning world of life science advancements has awakened investors' interest with its financial and healthcare potential.
A team of Department of Energy scientists led by Oak Ridge National Laboratory has released the first-ever dataset bridging molecular information about the poplar tree microbiome to ecosystem-level processes. The project aims to inform research regarding how natural systems function, their vulnerability to a changing climate, and, ultimately, how plants might be engineered for better performance as sources of bioenergy and natural carbon storage.
Two newly discovered genetic variations can have a powerful effect on a person's risk for obesity, a new report says. Variants in the gene BSN, also known as Bassoon, can increase risk of obesity as much as sixfold, researchers report April 4 in the journal Nature...
Researchers from the Medical Research Council (MRC) have discovered rare genetic variants in two genes, BSN and APBA1, that can dramatically increase the
Potentially good news for the nearly 100,000 Americans on the transplant waiting list.
The study identified genetic variants in two genes that have some of the largest impacts on obesity risk discovered to date.
/PRNewswire/ -- The International Medical Congress of the SCO countries was held on 27-29 March in Bishkek, Kyrgyzstan, under the theme "Innovations and...
In May 2022, cattle across India began dying of a mysterious illness. Since then, about 1,00,000 cows have lost their lives to a devastating outbreak of what scientists have identified as lumpy skin disease. The outbreak has severely affected India's agricultural sector, leading to staggering economic losses.
The genetic lottery of handedness just got a little bit more complicated.
Heres how complex social dynamics in pack animals like hyenas may shed light on the deep-seated biological impact of rank and community in the animal kingdom.
It's one of the biggest questions in science: to what extent are we defined by our genetics? A new analysis of Ludwig van Beethoven's DNA, showing a low predisposition for beat synchronization, hints that we can become much more than our genes suggest.
Champions of xenotransplantation see it as the solution to organ shortages across the world. But this technology has other applications.
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/PRNewswire/ -- Zymo Research Corp., a leader in biotechnology innovation, has unveiled the company's 'Graduate Student Starter Pack'. This new program is...
Regrowing limbs starts with protein and now, researchers know which protein are necessary.
Somite.ai aims to improve the lives of millions of people by leveraging AI to produce human tissue for cell therapies.
Turning off a gene early in mouse development led researchers to end up with an accidental six-legged embryonic mammal.
Its one of lifes most defining momentsthat crucial step in embryonic development, when an indistinct ball of cells rearranges itself into the orderly three-layered structure that sets the stage for all to come. Known as gastrulation, this crucial process unfolds in the third week of human develop
Scientists at NPL worked with Diamond Light Source to publish a study that shows how the chemistry of human cells changes, depending on the structure of their extracellular niche, are major determinants of cell responses and development pathways. The paper is published in ACS Applied Materials & Interfaces.
Some stem cells have a natural ability to divide into more cells and develop into various specialized blood, bone or muscle cells. These pluripotent stem cells offer great promise for new cell treatments and regenerative medicine, researchers say.
A collaboration between research groups at the University of California, TU Dresden in Germany and Cedars-Sinai Guerin Children's in Los Angeles has identified a mechanism by which embryonic cells organize themselves to send signals to surrounding cells, telling them where to go and what to do. While these signaling centers have been known to science for a while, how individual cells turn into organizers has been something of a mystery.
Pressure determines which embryonic cells become "organizers" that tell other cells where to go and what to do, researchers report.
A collaboration between research groups at the University of California, TU Dresden in Germany and Cedars-Sinai Guerin Children's in Los Angeles has identified a mechanism by which embryonic cells organize themselves to send signals to surrounding cells, telling them where to go and what to do. While these signaling centers have been known to science for a while, how individual cells turn into organizers has been something of a mystery.
In a study published in Cell Stem Cell, researchers led by Profs. Dai Jianwu and Zhao Yannan from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have demonstrated the remarkable role of early developmental spinal cord extracellular matrix (ECM) in promoting neuronal axon growth and functional maturation, as well as enhancing the therapeutic efficacy of neural progenitor cells (NPCs) and spinal cord organoids in rat spinal cord injury (SCI).
Just when scientists thought they had almost figured out the origins of multicellular life, evolution throws another curveball.
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/PRNewswire/ -- Integrated Oncology Network (ION), in partnership with California Cancer Associates for Research & Excellence (cCARE), is excited to welcome...
Moderna is developing a vaccine-based treatment for solid tumors. Read why I would not say that the oncology platform alone makes MRNA a clear buy.
/PRNewswire/ -- More hope for successfully combating some of the deadliest cancers. Lamassu Biotech is proud to announce its pioneering effort to combat...
/PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today the approval of the CE Mark for the VENTANA HER2 (4B5) Rabbit Monoclonal Primary Antibody...
Scientists discovered which tumor cells resist treatment and why. By characterizing B-cells' developmental stages, they designed and tested a drug combination to effectively treat resistant B-cell leukemia.
Researchers at the Netherlands Cancer Institute have compiled a detailed catalog of bacteria living in cancer metastases. Having analyzed over 4000 tumors, they shed light on the diversity of these co-inhabitants and how they might interact with cancer cells and their surroundings. For example, cert
/PRNewswire/ -- OOFOS, the global leader in Active Recovery footwear, today proudly announces a monumental achievement in their Project Pink initiative,...
/PRNewswire/ -- Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies...
/PRNewswire/ -- GT Medical Technologies, Inc. (GT MedTech), a medical device company with the mission of improving the lives of patients with brain tumors,...
/PRNewswire/ -- GenFleet Therapeutics, a clinical-stage biotechnology company focusing on cutting-edge therapies in oncology and immunology, today unveiled the...
/PRNewswire/ -- GenFleet Therapeutics, a clinical-stage biotechnology company focusing on cutting-edge therapies in oncology and immunology, today announced...
Rosen was one of more than 275,000 cancer patients in the United States who are infused each year with fluorouracil, known as 5-FU, or, as in Rosens case, take a nearly identical drug in pill form called capecitabine.
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Only recently, a new era in medicine began with the first RNA vaccines. These active substances are modified RNAs that trigger immune responses of the human immune system. Another approach in RNA medicine targets the body's own RNA and its protein modulators by specifically tailored active substances.
Scientists discovered a previously unidentified rogue immune cell linked to poor antibody responses in chronic viral infections. Australian researchers have discovered a previously unknown rogue immune cell that can cause poor antibody responses in chronic viral infections. The discovery, recently
/PRNewswire/ -- Model Medicines, a leading human health company specializing in generative AI-driven drug discovery, today announced the publication of two...
/PRNewswire/ -- EFISHient Protein, a leading Israeli FoodTech company, proudly announces the successful completion of the Tilapia cell line development. This...
In the clandestine world of biochemical warfare, researchers are continuously seeking innovative strategies to counteract lethal agents. Researchers led by Jin Kim Montclare, Professor in the Department of Chemical and Biomolecular Engineering, have embarked on a pioneering mission to develop enzymatic defenses against chemical threats, as revealed in a recent study published in ChemistryOpen.
In a new paper published in Molecular Biology of the Cell, the Allain lab (IBC) reported that the phase separation of the SARS-CoV-2 N protein strongly depends on the chosen buffer and pH. For example, the protonation of a single histidine side chain makes the difference if the protein phase separates or not.
Did you know that the world's deadliest animal is the mosquito? And Aedes aegypti is one of the most dangerous. This bug spreads viruses that cause dengue fever, which was recently declared as an epidemic in Puerto Rico.
A new study looking at the replication stage of the SARS-CoV-2 virus that causes COVID-19 reveals important mechanisms in its replication that could be the foundation for new antiviral therapies.
Viruses need hosts. Whether it's measles, the flu or coronavirus, viral pathogens cannot multiply or infect other organisms without the assistance of their hosts' cellular infrastructure. However, humans are not the only ones affected by viruses: animals, plants and even microorganisms can all serve as hosts.
Visual marker in petunia flowers sheds light on a little-known process. A research team led by Purdue University has begun translating the intricate molecular language of petunias. The grammar and vocabulary of this language are deeply concealed within the countless proteins and other compounds tha
PROTACs use the natural garbage disposal machinery within cells to tag and remove problematic proteins, with potential applications ranging from cancer to pesticides.
Researchers from Aarhus University and the Italian Institute of Technology have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that ar
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Humans can sense five different tastes: sour, sweet, umami, bitter, and salty, using specialized sensors on our tongues called taste receptors. Other than allowing us to enjoy delicious foods, the sensation of taste allows us to determine the chemical makeup of food and prevents us from consuming toxic substances.
Scientists at Scripps Research have developed atomic-level structural models of enzymes linked to autoimmune and inflammatory conditions, such as lupus and Alzheimer's disease. When nucleic acids, such as DNA or RNA, accumulate in a cell's cytoplasm, they trigger an alert to the immune system. Unde
/PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, today...
When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system. Enzymes usually clear these nucleic acids before they cause an issue, but when these enzymes don't work and the immune system gets called in, it can lead to autoimmune and inflammatory diseases.
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate semialdehyde dehydrogenase deficiency (MMSDH deficiency), an autosomal recessive disorder, arises from mutations in the ALDH6A1 gene. Additionally, ALDH6A1 has emerged as a biomarker for several types of severe cancer. Despite its significance, the structural and biochemical mechanisms of ALDH6A1 r
A new study provides insights into how a family of immune proteins in plants confers disease resistance. The study builds on previous research by the same research group, which highlighted the structural similarities of this protein family between plant and animal immune systems.
/PRNewswire/ -- XtalPi, a leading global technology company in integrating artificial intelligence (AI) and robotics to advance the discovery of groundbreaking...
Researchers have advanced the understanding of membrane protein dynamics by studying bacteriorhodopsin (bR) with innovative methods combining atomic force microscopy and light triggers. When it comes to drug development, membrane proteins play a crucial role, with about 50% of drugs targeting the
Researchers have identified a new complex-carbohydrate biomolecule, or glycan, that plays a key role in the nasal colonization of the Bordetella bacteria responsible for whooping cough. The discovery could make it possible to create a new drug or vaccine that interferes with the glycan to greatly reduce or even stop ongoing Bordetella transmission.
Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.
When you are reading this article, there are multiple hormones working diligently inside your body to stabilize your health status. Just as in human beings, it is impossible for plants to grow and reproduce without being regulated by phytohormones. One of the phytohormones is the brassinosteroid (BR) hormone, also named as the sixth phytohormone.
Researchers from the University of Southampton have developed technology to help scientists observe proteins in motion. Understanding how proteins move will allow novel drugs to be designed.
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