In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated
Theyve already done it in mice. With new company, they hope to transfer those studies and hopefully similar results to humans.
New study from neuroscientists at Vanderbilt provides initial answers to long-standing scientific questions on what causes the transition from moderate to compulsive alcohol consumption - and what makes some drinkers particularly vulnerable to developing alcohol use disorders.
UNC School of Medicine researchers are learning about the differences in the underlying biology of patients with severe and milder forms of Alexander disease, a rare neurodegenerative condition that is often fatal to young children. Led by Natasha Snider, PhD, assistant professor of cell biology, an international group of scientists has discovered that the mutant form of GFAP undergoes different chemical modifications, depending on time of onset of symptoms.
Although alcohol use is ubiquitous in modern society, only a portion of individuals develop alcohol use disorders or addiction. Yet, scientists have not understood why some individuals are prone to develop drinking problems, while others are not. Now, Salk Institute researchers have discovered a brain circuit that controls alcohol drinking behavior in mice, and can be used as a biomarker for predicting the development of compulsive drinking later on.
A research team led by The University of Western Australia has found that our cells deteriorate and share fewer resources as we age, which can lead to the onset of diseases such as osteoporosis, arthritis, cardiovascular disease and cancers.
The brain cortex, the outside layer of our brain often referred to as grey matter, is one of the most complex structures found in living organisms. It gives us the advanced cognitive abilities that distinguish us from other animals. Neuroscientist Professor Pierre Vanderhaeghen (VIB-KU Leuven, Un
Charcot-Marie-Tooth disease (CMT) is an inherited neurodegenerative condition that affects 1 in 2500 individuals. Currently, however, it is still lacking effective treatment options. New research has demonstrated that a class of cytoplasmic enzymes called tRNA synthetases can cause CMT by interfering with the gene transcription in the nucleus. This breakthrough is the result of an international academic collaboration, where scientists from the VIB-UAntwerp Center for Molecular Neurology and the
With unexpected findings about a protein that's highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism. Their discovery, which appears in Nature, could lead to new approaches for addressing obesity and potentially many other diseases.
Harvard Medical School neuroscientists have decoded how visual cues can rapidly reorganize the activity of compass neurons in fruit flies to maintain an accurate sense of direction. By tracking individual neurons as flies navigate a virtual reality environment, the researchers shed light on neural mechanisms that allow organisms to build a spatial map of their world, as well as processes involved in short-term memory.
/PRNewswire/ -- IFM Therapeutics, LLC (IFM), a privately-held biopharmaceutical company focused on developing therapies that modulate novel targets in the...
Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn comes to this conclusion in the journal Nature. The results indicate that inflammatory processes represent a potential target for future therapies.
The former West Ham defender on a tragedy shaping the next phase of his life and why he briefly gave up caring at Southend
The transplanted cells turned into fully functional lungs that kept the otherwise lung-less host mice alive well past birth.
A three-dimensional computer model enables scientists to quickly determine which genes are active in which cells, and their precise location within an organ. A team led by Nikolaus Rajewsky, Berlin, and Nir Friedman, Jerusalem, has published the new method and their insights gained from this in Nature.
Scientists at Gladstone Institutes, in collaboration with researchers at Boston University, have used a computational model to learn how to coax stem cells into forming new arrangements, including those that might eventually be useful in generating personalized organs.
MIT researchers can now identify T cells reactive to a particular target from a patient's cells, and to perform high-throughput single-cell RNA sequencing of those cells.
Scientists at the University of Würzburg have successfully produced human tissues from stem cells. They have a complexity similar to that of normal tissue and are far superior to previous structures.
Mitochondria, often thought of as the powerhouses of cells, are just one part of a larger living thing, but they are unique among cellular structures in that they have their own DNA that is distinct from that of their parent cells. And just like their parent cells, mitochondria need quality-control mechanisms to maintain their DNA and preserve their normal function.
Workingout your pet's age in 'dog years' simply by multiplying it by seven is actually a myth.
Max Planck researcher develops a method for measuring gene expression noise across single cells in complex tissue.
Researchers of the Josep Carreras Leukaemia Research Institute discover that a leukaemic cell is capable of transforming into a non-cancerous cell through epigenetic changes.
Researchers have devised a new plan of attack against a group of deadly childhood brain cancers collectively called diffuse midline gliomas (DMG),
A new mathematical model uses the size of a cancer patient's initial, primary tumor to predict whether undetectable secondary tumors are already present. Stefano Avanzini and Tibor Antal of the University of Edinburgh, UK, present the model in PLOS Computational Biology.
Researchers from the CIBER-BBN and the Universitat Autònoma de Barcelona use bioengineering to design non-toxic drug-release granules to be administered locally and with prolonged therapeutic effects.
Scientists from Imperial and the University of Bergen have found a new way to predict how a disease will likely progress in individual patients.
According to a new Cell study, extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going -- elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat.
Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center analyzed data from pancreatic cancer clinical trials to understand how treatment responses and drug resistance linked to tumor subtypes.
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/PRNewswire/ -- iOmx Therapeutics AG (iOmx), a biopharmaceutical company developing cancer therapeutics based on novel immune checkpoint targets, announced...
Researchers have devised a new, promising plan of attack against deadly childhood brain cancers called diffuse midline gliomas (DMG). NCATS and Stanford University scientists and their colleagues showed that combining two drugs killed DMG patient cells grown in the laboratory and in animal models. The drugs countered the effects of a genetic mutation that causes the diseases. Their studies also uncovered an unrecognized vulnerability in the cancer cells that scientists may be able to exploit.
Vyriad's work with biotech drugmaker Regeneron will also focus on lung, liver and uterus cancers.
By analyzing over a million nucleic acid sequences from publicly available data, a team of researchers has identified 111,582 fusions in eight species (human, mouse, rat, fruit-fly, wild boar, zebrafish, yeast and cattle). The latest and most up-to-date version of their database, known as ChiTaRS, will be extremely useful to clinicians specializing in complex diseases, particularly, cancers, Alzheimer's disease, schizophrenia and many others.
A sample of estuarine mud taken 16 years ago has yielded a potential new class of painkiller as potent as opioids, but without their disadvantages. Researchers from The University of Queensland and University of Sydney have filed a patent application for the potential drug, which is a modified ve
Wound healing in mucous tissues during early infection by Simian Immunodeficiency Virus guards some primate species against developing AIDS, Both HIV and SIV provoke an immune response that injures tissues surrounding the intestine, African green monkeys with SIV quickly repair their mucous tissues. This interrupts the disease course and avoids AIDS onset. Stimulating this response might be a way of treating HIV in people.
A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.
An experimental HIV vaccine developed by scientists at Scripps Research and the nonprofit vaccine research organization IAVI has reached an important milestone by eliciting antibodies that can neutralize a wide variety of HIV strains. The tests, in rabbits, showed that these ''broadly neutralizing'' antibodies targeted at least two critical sites on the virus. Researchers widely assume that a vaccine must elicit bnAbs to multiple sites on HIV if it is to provide robust protection against this ev
/PRNewswire/ -- The International Center for Materials Nanoarchitectonics (WPI-MANA), a unit of the National Institute for Materials Science (NIMS), had a...
Killer cells of the immune system detect and kill infected cells or cancer cells. Researchers at the Institute of Pathology at the University of Bern have now discovered that the mechanism by which certain immune cells kill their target cells can also be used to control the killer cells themselves.
A discovery about how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus, say Melbourne researchers. The research team showed, in laboratory models, that strong inflammatory signals caused by malaria infection activate molecules that trigger the production of highly potent antibodies to fight the disease.
Indiana University researchers have identified a mechanism involving the body's ability to resist fungal infection. The work could help advance research on cancer therapies that use the body's own immune system to fight disease.
Indiana University researchers have identified how two immune receptors coordinate closely to trigger a powerful response against fungal invaders, which could help advance research on cancer therapies.
Tailored T-cells specially designed to combat a half dozen viruses are safe and may be effective in preventing and treating multiple viral infections, according to research led by Children's National Hospital faculty presented during a symposium jointly led by Children's National and the National Institute of Allergy and Infectious Diseases.
Taste and smell receptors in unexpected organs monitor the state of the bodys natural microbial health and raise an alarm over invading parasites.
ATP synthase is a universal molecular machine for energy conversion. By coupling to cellular respiration in mitochondria, it catalyzes conversion of chemical energy of cells.
SciLifeLab researchers Alexander Mühleip and Alexey Amunts from Stockholm University solved the structure of a mitochondrial ATP synthase with native lipids.
By solving a complex protein structure, biologists have unlocked a critical mechanism in plants that could lead to improvements in how photosynthesis works, and by consequence, greater crop yields.
Scientists have solved the structure of one of the key components of photosynthesis, a discovery that could lead to photosynthesis being 'redesigned' to achieve higher yields and meet urgent food security needs.
A team from Cape Town have recently published the first high-resolution cryo-electron microscopy (EM) paper to originate from Africa. As described in Nature Communications Biology, the team solved the structure of a nitrilases enzyme to a close-to-atomic resolution and used the structural insights to design a mutant enzyme that could be fine-tuned for applications in biotechnology. This work was made possible through an access program funded by the Synchrotron Techniques for African Research and
/PRNewswire/ -- The "Nothing Degrading about Saving Lives: E3 Ligands Recruiting New Drugs" report has been added to ResearchAndMarkets.com's offering....
A research group including researchers from the Exploratory Research Center on Life and Living Systems (ExCELLS), Institute for Molecular Science (IMS) in National Institutes of Natural Sciences, and Osaka University have revealed the detailed mechanism of the biosynthesis of carbon monoxide essential for the maturation of the active site of NiFe-hydrogenase.
One of the main factors favoring a microorganism's survival in extreme conditions is preserving ribosomes -- a macromolecular complex comprising RNA and proteins
Cooking spoons, spatulas or whisks: polyamide (PA) kitchen utensils provide valuable baking, roasting and cooking assistance. However, components of this plastic can migrate from the utensils into the food and consequently be ingested by consumers.
A research team at the University of California, Riverside, has discovered the structure of a novel RNA-modifying enzyme, ZCCHC4, and identified the mechanism that controls how this enzyme recognizes its substrate. ZCCHC4 influences cell proliferation and has been linked to cancers. The discovery has applications in structure-based drug design against cancers.
Scientists have produced a co-regulation map of the human proteome, which was able to capture relationships between proteins that do not physically interact or co-localize. This will enable the prediction and assignment of functions to uncharacterised human proteins. The co-regulation map can be explored at www.proteomeHD.net.