When the brain encodes memories as positive or negative, a small peptide called neurotensin determines which way they will go.
Neuroscientists show that its possible to turn the volume down on a negative memory by stimulating other, happier ones. Even though you may not realize it, each time you recall a memorysuch as your first time riding a bike or walking into your high school promyour brain changes the memory ever
Many people face persistent cognitive symptoms after COVID-19. A new study, which grew and examined 3D models of the human brain, offers a possible explanation as to why this might be.
Investigators have discovered that outer mitochondrial membrane proteins regulate crosstalk between mitochondria and lysosomes, according to a Northwestern Medicine study published in the Journal of Cell Biology. These findings have implications for the role of organelle networks in cellular homeostasis and the development of neurological diseases.
Exposure to flame retardant called FireMaster 550 before birth left newborn rats with altered brain development, research finds.
/PRNewswire/ -- Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) ("Alterity" or "the Company"), a biotechnology company dedicated to developing disease modifying...
Scientists reveal how an intranasally delivered oxytocin derivative could be used to treat Alzheimer's disease. Alzheimer's disease (AD), characterized by an accumulation of -amyloid protein (A) in brain tissue, is a leading cause of dementia. Researchers at Tokyo University of Science have previ
Microglia are a type of immune cell that works as a "janitor" to the central nervous system that clears out dead cells and other debris. But when these janitor cells themselves die, other microglia don't do the cleaning up of their fallen brethren. So who does? Researchers have now identified the janitors of these janitors, helping explain how the nervous system maintains optimal conditions for functioning.
Five proteins share important roles in the formation and function of synapses and can substitute for each other. This discovery was made by a team of the Karl Landsteiner University of Health Sciences Krems (KL Krems) and the CavX Ph.D. program of the Medical University of Innsbruck, and their work is now published in the International Journal of Molecular Sciences.
/PRNewswire/ -- Metabolon, Inc., the global leader in providing metabolomics solutions that advance a wide variety of research, diagnostic, therapeutic...
Chronic heart failure causes the cell's powerhouses to malfunction, in part due to overconsumption of an important intermediary compound in energy production. Supplementing the diet to compensate for this could prove a promising strategy for treating heart failure. The findings were published in the journal PNAS by Hokkaido University scientists and colleagues in Japan.
The promise and perils of applying artificial intelligence to drug discovery. And advice on how to avoid inconsolable regret in life.
"Zombie cells" both contribute to age-related disease and help heal important tissues.
Inside cells, molecular droplets form defined compartments for chemical reactions. Not only sticky interactions between molecules, but also dynamic reactions can form such droplets, as was found by researchers from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) and the University of Oxford. They revealed a new regulatory mechanism by which life controls and organizes itself.
Cells interact in various different ways and on multiple length-scales. The interaction of a cell with its tissue niche can be described through cell communication events. To understand these events, researchers around the world create models, based on different strategies. The knowledge is crucial to understand and identify emerging phenomena in tissue microenvironments, such as genetic changes in a tumor.
Patient-derived parathyroid organoids (PTOs) could pave the way for future physiology studies and drug-screening applications, as shown in a study published on October 27 in the journal Stem Cell Reports.
Japan extends from north to south, resulting in a huge diversity of climate and environmental conditions. Various endemic species have evolved in Japan as a result of their ability to adapt to diverse environmental conditions. Thus, Japan is a hotspot of animal diversity with a number of endemic species that are already, or are becoming, endangered. With the numbers increasing steadily in recent years, mainly due to human activities such as forest destruction and global warming, action must be t
He uses examples from his own medical career to underline the importance of cellular understanding | Culture
Your skin, other organs, and the hearts of newborn mice and humans can regenerate after being damaged, but adult hearts can't. Here's why.
The ability to analyze the properties of individual cells is vital to broad areas of life science applications, from diagnosing diseases and developing better therapeutics to characterizing pathogenic bacteria and developing cells for bioproduction applications. However, the accurate analysis of individual cells is a challenge, especially when it comes to a cell's biophysical properties, due to large property variations among cells even in the same cell population as well as the presence of rare
Research labs are pursuing technology to reprogram aging bodies back to youth.
The research team led by Prof. Guo Guoji and Prof. Han Xiaoping at the Zhejiang University School of Medicine have published an article titled "Deep learning of cross-species single cell landscapes identifies conserved regulatory programs underlying cell types" in the journal Nature Genetics on October 13.
/PRNewswire/ -- This month, North Carolina State University and TruDiagnostic take the next step in their investigation into the human imprintome with an...
As heart cells mature in mice, the number of communication pathways called nuclear pores dramatically decreases. Although this might protect the organ from damaging signals, it could also prevent adult heart cells from regenerating. This is according to new research conducted by scientists from the
According to TREY the Explainer, though Old World Europeans brought pestilence to the New World Americas, a fascinating tangent to this conquest arises from the European dogs that brought their own germs from the Old World, all but wiping out pre-contact dogs. Researchers have identified that European dogs have largely replaced their specialized pre-contact dog…
Device less than 1mm in diameter is designed to be inserted in body and produce images of tissue with ‘unprecedented speed’
See how cancer genome therapies benefit from artifical intelligence.
Peto's paradox refers to an apparently contradictory fact: if cancer happens due to DNA errors in the cells, why do animals with more cells get less cancer?
People receiving the therapies had fewer nightmares and more joyous dreams.
Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers. Scientists can build them in various shapes with different materials, often as porous, crystal-like structures formed by a lattice of metal and organic compounds, or as capsules that enclose their contents inside a shell. When injected into a tumor, these particles can release treatments that attack cancer cells directly or complement other treatments like imm
/PRNewswire/ -- Kazia Therapeutics Limited (NASDAQ: KZIA; ASX: KZA), an oncology-focused drug development company, is pleased to announce the presentation of...
Scientists around the world are researching how anti-cancer drugs can most efficiently reach the tumors they target. One possibility is to use modified bacteria as "ferries" to carry the drugs through the bloodstream to the tumors. Researchers at ETH Zurich have now succeeded in controlling certain bacteria so that they can effectively cross the blood vessel wall and infiltrate tumor tissue.
/PRNewswire/ -- SkinCure Oncology, the world leader in providing a comprehensive model for the delivery of Image-Guided Superficial Radiotherapy (Image-Guided...
/PRNewswire/ -- The Bracken Group is pleased to announce that Dr. Alexander "Sandy" McEwan, Executive Consultant and Senior Partner, will be joining the team....
/PRNewswire/ -- MIB Agents, a leading pediatric osteosarcoma nonprofit dedicated to Making It Better for its community of patients, caregivers, doctors, and...
/PRNewswire/ -- PetDx The Liquid Biopsy Company for Pets is pleased to announce that OncoK9, its first-in-class multi-cancer early detection (MCED) test...
Its possible that life on Earth may have started here repeatedly and around the same time at different spots on the globe, says one prominent astrobiologist.
If youre immunocompromised, this isnt great.
Human endogenous retroviruses were left behind as a result of infections that humanitys primate ancestors suffered millions of years ago.
Northwestern Medicine investigators have solved a challenging protein design puzzle using a unique high-throughput approach, according to a study published in Proceedings of the National Academy of Sciences.
Viral DNA in human genomes, embedded there from ancient infections, serves as antivirals that protect human cells against certain present-day viruses, according to new research.
New classes of antibodies may be one of our best tools to overcome new immune evasive variants.
Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs. The discovery, published in the October 26, 2022 issue of Nature, opens the possibility of new therapies, including for multiple forms of cancer.
(The Conversation is an independent and nonprofit source of news, analysis and commentary...
Even if youve gained some immunity to covid-19 by getting vaccinated or recovering from the disease, its hard to know how vulnerable you might still be. Now MIT researchers have developed an easy-to-use test that may reveal just that. Using the lateral flow technology familiar from home covid and pregnancy tests, it measures the level
We're used to thinking of the immune system as a separate entity, almost a distinct organ, but the truth is much more complicated. Breakthroughs in recent yearssome resulting from research performed in Prof. Rotem Sorek's lab at the Weizmann Institute of Science's Molecular Genetics Departmenthave shown that individual bacterial cells possess their own autonomous, innate immune system that can identify, locate and deal with intruders.
The virus, created in the fusion of influenza A and RSV, has never been observed before.
A new method to study the proteins released by cells, which could lead to the development of new tools to track diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London.
/PRNewswire/ -- ANGUS Chemical Company ("ANGUS" or "Company"), a leading global manufacturer and marketer of specialty chemicals for Life Sciences and...
Over the last decade, the lush olive groves one associates with the Italian countryside have become desiccated, as if stuck in a perpetual winter. The culprit is Xylella fastidiosa, a species of aggressive bacteria that have caused devastating epidemics in several important crops. X. fastidiosa now threatens almonds, olives, and grapevinesstaples of Europe's economy and cuisine.
Membrane proteins are key targets for many drugs. They are located between the outside and inside of our cells. Some of them, called transporters, move certain substances in and out of the cellular environment. Yet, extracting and storing them for observation is particularly complex.
A mechanism used by a fungal pathogen to promote spread of the devastating cereal crop disease, blast, has been revealed in fine detail.
Protein arginine methylation plays an important role in regulating protein functions in different cellular processes, and its dysregulation may lead to a variety of diseases.
Being able to precisely monitor concentrations of biomoleculesimportant for following diseases and adjusting treatmentsrequires not only highly specific and sensitive sensors, but also that measurements can take place continuously, over long periods of time.
Cornell scientists have created an evolutionary model that connects organisms living in today's oxygen-rich atmosphere to a time, billions of years ago, when Earth's atmosphere had little oxygenby analyzing ribonucleotide reductases (RNRs), a family of proteins used by all free-living organisms and many viruses to repair and replicate DNA.
University of California, Santa Cruz, scientists report the creation of three crystal structures of periodic rippled beta sheets, a novel protein structure. A peculiar protein structure known as a "rippled beta sheet," which was initially hypothesized in 1953, has now been generated in the labora
Tokyo Tech developed a new cell-free protein crystallization (CFPC) method that includes direct protein crystallization and is a major advancement in the field of structural biology. This technique will enable the analysis of unstable proteins that couldn't be studied using conventional methods. Ana
Each day, millions of biological processes occur in our body at a cellular level. Studying these processes can help us learn more about how cells function, a field that has continued to intrigue researchers. Recently, however, there has been a new player in this field. A new analytical methodsingle-molecule detectionhas gained momentum due to its success in observing specific, biologically relevant molecules and the processes associated with them.
As task forces of the adaptive immune system, T lymphocytes are responsible for attacking and killing infected or cancerous cells. Such cells, like almost all cells in the human body, present on their surface fragments of all the proteins they produce inside. If these include peptides that a T lymphocyte recognizes as foreign, the lymphocyte is activated and kills the cell in question.
/PRNewswire/ -- InsightAce Analytic Pvt. Ltd. has announced the publication of a market research report titled "Global 3D protein structure analysis Market by...